I head the Computational Biology Group at the University of Cape Town (UCT) (http://www.cbio.uct.ac.za) and Coordinate a Pan African Bioinformatics Network, H3ABioNet. After my PhD in Medical Microbiology, I spent 8 years at the European Bioinformatics Institute (EBI) in Cambridge, moving into the area of bioinformatics. At the EBI I was a Team Leader, responsible for development of InterPro, one of the most heavily used Bioinformatics resources at the Institute, and also coordinated the Gene Ontology Annotation project. At UCT I work in the area of bioinformatics of infectious diseases, including pathogen and host genomics and biological networks, human variation studies and disease associations. The group also provides bioinformatics support and training for postgraduate students and local researchers. I am President of the African Society for Bioinformatics and Computational Biology and coordinate H3ABioNet, which includes 34 African institutions in 16 countries.